ÐÏࡱá>þÿ xzþÿÿÿwÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Áeà ø¿X*bjbj:´:´ 8ZXÞg\XÞg\¹!žÿÿÿÿÿÿ·  ~~~~~ÿÿÿÿ’’’8Ê„N<’…ZЦLòòò&"H\ ZZZZZZZ$¡\¶W_”*Z~h&&hh*Z~~òò4?ZžžžhF~ò~òZžhZžž`S€xWòÿÿÿÿPP¤!øÓÿÿÿÿ®RàT,ðYUZ0…Z Ulë_hë_XxWë_~xWxhhžhhhhh*Z*Zh6hhh…Zhhhhÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿë_hhhhhhhhh > D: [INSERT ELECTRONIC DEPARTMENT LETTERHEAD ON PAGE 1] Emergency Use Template v. 5/30/2018 RSRB Requirements: Information highlighted in yellow is guidance. Ensure ALL HIGHLIGHTED TEXT is deleted before submitting. Use of 2nd Person: The consent form must be written in the 2nd person (e.g., “This treatment is being recommended for you because…”). Pagination: Maintain page numbering already inserted in the footer (e.g., “2 of 4”). Version Date: Manually type the date in the footer, rather than selecting “Insert Date” from the toolbar to avoid automatic updates each time the document is opened. Margins: Maintain the bottom margin of at least 2 inches to provide space for watermarking upon approval. CONSENT FORM Emergency Use of an Unapproved [Drug/Biologic/Device] Treating Physician: [Insert name] (If applicable)If you are the parent of a child or the authorized representative of an adult patient who will receive this treatment, the use of the word “you” in this form refers to the patient receiving the treatment. Introduction You have been diagnosed with [insert]. This is a life threatening or severely debilitating condition that requires treatment right away. The purpose of this form is to explain your options for treatment with an investigational [drug/device] called [insert]. An investigational [drug/device] is one that has not been approved by the Food and Drug Administration (FDA) and is currently only available for research. This treatment is being recommended for you because:  FORMCHECKBOX  There are no appropriate alternative treatments available for this condition.  FORMCHECKBOX  Alternative treatments for this condition have been tried and have failed. Although clinical studies to determine the safety and effectiveness of the [drug/device] may be ongoing, you will be given this [drug/device] to try and treat your condition outside of the clinical trial. This use of an investigational [drug/device] is known as an “Emergency Use” and is permitted by the FDA. Description of the Treatment Describe, in plain language, step-by-step the treatment. As appropriate include: How the drug is given (e.g., oral, IV, IM), its dose, when it will be given and for long it will be given. How the device is administered/implanted and monitored Any additional tests/procedures that the patient may need to undergo as part of the treatment. Risks and Discomforts Describe, in plain language immediate and long-term physical, psychological, social, legal and economic risks/discomforts of both the investigational drug/device and any additional tests/procedures that the patient may need to undergo as part of their treatment. If appropriate, include information on the probability of the risk and the magnitude and reversibility of harmful effects (categorizing side effects as “Likely”, “Less Likely” and “Rare” is helpful). Describe how the risks/discomforts will be minimized. Because this treatment is considered investigational, there may also be risks or side effects that we do not know about at this time. Benefits You might not benefit from this treatment. It is hoped that the treatment will [insert – e.g., improve your X, stop/slow its progression, etc.], but this cannot be guaranteed. Costs Choose or modify ONE of the following sentences as appropriate: [Insert drug/device] will be provided free of charge. You and/or your medical insurance company are responsible for payment of your hospital stay and regular doctor’s visits. - OR - The treatment including the [cost of the drug/device, laboratory tests and diagnostic tests] you receive will be charged to you or your insurance company just as any other medical care would be. Your insurance may or may not pay for this treatment. You should check with your insurance company to find out what costs they will pay. If your insurance company will not pay for this treatment, you will be billed for the cost of the treatment and all other related expenses. Confidentiality of Records and Authorization to Use and Disclose of Information The ÌìÃÀ´«Ã½ makes every effort to keep the information collected from you private. In order to do so, we will [insert protection measures]. Sometimes, however, physicians need to share information that may identify you with people that work for the University, regulators or the treatment sponsor. If you have never received a copy of the ÌìÃÀ´«Ã½ Medical Center (URMC) and Affiliates Notice of Privacy Practices, please ask the investigator for one. [Note to Investigators: the Notice must be provided and receipt documented if this is the first contact with URMC and Affiliates (copies available on web).] What information may be used and given to others? The doctor will get your personal and medical information. For example: Past and present medical records related to this treatment, including records of external providers that are available via your electronic health record at URMC & Affiliates Results of medical tests Observations made while you undergo the treatment Who may use and give out information about you? Your doctor and the treatment team URMC and Affiliates Your information may be given to: The Department of Health and Human Services The ÌìÃÀ´«Ã½ [Include every organization or individual where data is shared (i.e., sponsors, sponsor agents [e.g., CRO], data monitoring committees, government agencies, foreign government regulatory agencies, companies, coordination centers, data management centers, other sites, etc. who might receive, and/or use the information) The U.S. Food and Drug Administration (FDA) may also need to inspect the treatment records at some point during your treatment or even after it has been completed. In the event that this should occur, every effort will be made to keep identifying information about you private. Why will this information be used and/or given to others? To conduct the treatment To measure the effects and safety of the treatment To see if the treatment was done right If the results of this treatment program are made public, information that identifies you will not be used. What if I decide not to give permission to use and give out my health information? Then you will not be able to receive this treatment. May I review or copy my information? Yes, but only after the treatment program is over. How long will this be permission be valid? This permission will last indefinitely. [If you will destroy the records at a definite point that should be stated instead and should be consistent with what is listed in both your protocol and application.] May I cancel my permission to use and disclose information? Yes. You may cancel your permission to use and disclose your health information at any time. You do this by sending written notice to your doctor. Upon receiving the written notice, the treating team will no longer use or disclose your health information and you will not be able to stay on this treatment program. Information that has already been gathered may need to be used and given to others for the validity of the treatment. May I withdraw from the treatment program? Yes. If you withdraw your permission to be in the treatment program, no new health information identifying you will be gathered after that date. Information that has already been gathered may still be used and given to others. Is my health information protected after it has been given to others? No. There is a risk that your information will be given to others without your permission. Voluntary Treatment Your decision to have this treatment is voluntary. You don’t have to accept this treatment, or can accept and then change your mind at any time. Contact Person(s) If you have any questions about the treatment, contact [insert treating physician’s name] at [telephone number]. ** If possible signature blocks should appear all on one page. SIGNATURES/DATES Patient Consent: I have read the contents of this consent form, asked questions and received answers. I agree to this treatment. 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