ÐÏࡱá>þÿ _aþÿÿÿ^ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Á€ ð¿„bjbjöàöà *X”ДЕîÿÿÿÿÿÿ·EEEEEÿÿÿÿYYY8‘$µÜY„)â‘‘‘‘‘lll')))))))))))))f+¢.Ð))Elllll))EE‘‘Û>)ÒÒÒl¾E‘E‘')Òl')ÒÒªO'|Ç(‘ÿÿÿÿðPaŽ~­ÎY*‚Ë')T)0„)Ý'êØ.¬&Ø.$Ç(Ø.EÇ(LllÒlllll))))Òlll„)llllÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿØ.lllllllll : All Questions must be answered YES for the subject to be enrolled in the study. INCLUSION CRITERIACOMMENTYES (Y) or NO (N)1. Male or Female 18 yrs and olderY N2. Body weight of ( 40kgY N3. Currently have a diagnosis of XXX that is either: related to …. related to …. OR associated with ….Y NHave a documented / confirmed history of XXXY NIf on XXX, must be at the maximal dose of XXmg BID for a minimum of 12 Weeks prior to screening and have a screening AST/ALT < 3 times ULNY NHave a chest X-Ray within 6 months of Screening that shows clear lung fields or no more than mild patchy (not diffuse) interstitial infiltrates. Y NHave no evidence of significant lung disease as evidenced by pulmonary function tests within 6 months of screening showing total lung capacity ( 60% predicted.Y NHave a XX test results of XXX. Y NHave a XXXY NA female subject of childbearing potential must have a negative serum pregnancy test at the screening visit and agree to use two medically reliable methods of contraception until study end.Y NWritten informed consent (and written assent for minors) will be obtained prior to any study procedures being performed. Y NINCLUSION Comments: ________________________________________________________________________ ______________________________________________________________________ All Questions must be answered NO for the subject to be enrolled in the study. EXCLUSION CRITERIACOMMENTYES (Y) or NO (N)Is patient pregnant or nursing?Y NHave related to conditions other than specified in inclusion criteria, including but not limited to XXX.Y NResting arterial oxygen saturation (SaO2) < 88% on room air at screening. Y NHistory of left-sided heart disease including any of the following: clinically significant aortic or mitral valve disease ( ex. aortic stenosis, aortic insufficiency, mitral stenosis, moderate or greater mitral regurgitation) pericardial constriciton restrictive or congestive cardiomyopathy left ventricualar ejection fraction < 40% by MUGA, angiography, or echocardiography life threatening cardiac arrythmiasY NHistory of surgery within 3 months before study entryY NHave severe renal insufficiency, defined as receiving renal dialysis or having measured or estimated creatinine clearance (CC) < 30mL/min Cockroft-gault formula at screeningY NHave a systolic blood pressure >160mmHg or < 90mmHg or have a distolic blood pressure > 100mmHg or < 50mmHg.Y NHave a history of angina pectoris or other condition that was treated with long or short acting nitrates within 12 weeks before administration of study drug.Y NHave a musculoskeletal disorder or any other disease other than XXXX.Y NHave a history of HIV.Y NHave any therapy an investigational drug within 4 weeks of administration of study drug.Y NHave any chronic medication except for anticoagulants discontinued within 4 weeks prior to administration of study drug.Y NAre investigator site personnel directly affiliated with the study, or the immediate family of the investigator site personnel directly affiliated with the study. 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